منابع مشابه
Arsenic carcinogenicity testing.
Chappell et al. (1) propose several valid ideas and procedures for accomplishing better drinking water standards for arsenic, a metalloid long known to be carcinogenic to humans (2-4). Another necessary recommendation , and in our opinion an obvious need, apparently not stated specifically in the Chappell et al. review on arsenic (1) is that we should test arsenic for long-term toxicity-and car...
متن کاملRe: Arsenic carcinogenicity testing.
In their letter to EHP, Huff et al. (1) maintained that arsenic is still viewed as "a paradoxical carcinogen; that is, carcinogenic to humans but not to laboratory animals," and that this paradox will be believed until car-cinogenicity of arsenic is demonstrated in animal experiments such as "long-term inhalation studies using arsenic trioxide." Huff et al. (1) seem not to take into considerati...
متن کاملTwo-year carcinogenicity study of acrylamide in Wistar Han rats with in utero exposure.
Acrylamide is an important chemical with widespread industrial and other uses in addition to generalized population exposure from certain cooked foods. Previous rat studies to assess the carcinogenic potential of acrylamide have been carried out exclusively in the Fischer 344 rat with identification of a number of tumors amongst which mesotheliomas of the tunica vaginalis is an important tumor ...
متن کاملPrediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing.
Twenty-four organic compounds currently undergoing testing within cancer bioassays under the aegis of the U.S. National Toxicology Program (NTP) were submitted to the computer automated structure evaluation (CASE) and multiple computer automated structure evaluation (MULTICASE) system for predictions of activity. Individual predictions resulting from the NTP combined rodent, NTP mouse, Carcinog...
متن کاملTesting chemical carcinogenicity by using a transcriptomics HepaRG-based model?
The EU FP6 project carcinoGENOMICS explored the combination of toxicogenomics and in vitro cell culture models for identifying organotypical genotoxic- and non-genotoxic carcinogen-specific gene signatures. Here the performance of its gene classifier, derived from exposure of metabolically competent human HepaRG cells to prototypical non-carcinogens (10 compounds) and hepatocarcinogens (20 comp...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 1998
ISSN: 1091-5818,1092-874X
DOI: 10.1080/109158198226611